Khoo Khe Sin received her B.Mus. degree from UCSI University with a certification from the University of Newcastle (Australia), as well as her M.M. and D.M.A. degrees from West Virginia University (USA). Her teachers include Prof. Dr. Peter Amstutz and Prof. Dr. Tean Hwa P’ng.

A multi-award recipient, Khe Sin had served as graduate assistant to the WVU Opera and Theater department, as well as studio accompanist and piano instructor at WVU. Her achievements include winning the 2006 WVU Young Artist Competition, as well as serving as staff accompanist at the National Association of Teachers of Singing (NATS) Tri-States Regional Competition (2012 and 2013), and at the International Flute Symposium at WVU (2012).

Since returning to Malaysia in 2014, Khe Sin has been active in the performing arts scene, collaborating with both local and international artistes and production companies. As an educator, she teaches privately and serves as an adjunct lecturer at UCSI University Institute of Music in Kuala Lumpur.